How long does it take for Epiduo to work?

First improvements are often visible after 4-8 weeks. The full effect develops over 12 weeks. Patience is important, even if there is initially a deterioration.

Why is my skin getting worse at first?

The so-called 'pollution phase' is normal. Adapalen accelerates the skin cycle, making hidden impurities come to the surface more quickly. This improves after 4-6 weeks.

May I use Epiduo in pregnancy?

No, Epiduo is contraindicated in pregnancy. Adapalen is a retinoid and can harm the unborn child. Women of the age of birth must be prevented.

What is the difference between Epiduo and Epiduo Forte?

Epiduo Forte contains a higher concentration of adapals (0.3% instead of 0.1%). It is intended for more stubborn acne that does not sufficiently appeal to the normal epiduo.

Can I apply sunscreen over Epiduo?

Yes, sun protection is even important, since adapals make light sensitive. Apply a non-comedogenic sunscreen (LSF 30+) in the morning after cleaning.

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What is epiduo?

Epiduo is a prescription gel for the topical treatment of acne vulgaris. It combines two proven active ingredients: the retinoid adapalen and the antibacterial benzoyl peroxide.

This combination combats acne on several levels – it opens clogged pores, reduces inflammation and kills acne bacteria. Epiduo is particularly suitable for medium-heavy acne and can be used both in young people and adults.

There are also Epiduo Forte with higher concentration (adapals 0.3%, benzoyl peroxide 2.5%) for more persistent cases.

Active Ingredients & Mechanism of Action

Active ingredient: Adapalen 0,1%, Benzoylperoxid 2,5%

The active ingredients in Epiduo complement each other optimally:

Adapals (0.1%):

belongs to the retinoids (vitamin A derivatives)
Normalizes the cornification of the skin
Prevents the formation of new comedons (center)
Has anti-inflammatory properties
Promotes cell renewal

Benzoyl peroxide (2.5%):

Works strongly antibacterially against Propionibacterium acnes
Release oxygen, which kills anaerobic bacteria
No resistance development possible
Lightly keratolytic (fooling)

Advantages of the combination: The simultaneous action on comedons, inflammation and bacteria makes Epiduo one of the most effective topical treatments for medium-heavy acne.

Who is it suitable for?

Epiduo is suitable for:

Patients from 9 years old with moderate acne vulgaris
In the case of predominantly flammable acne (papers, powders)
In mixed acne with comedons and inflammation
If individual active substances do not act sufficiently

Especially suitable for:

persistent acne that does not respond to milder treatments
Combination of mitess and inflamed pimples
young people with public acne

More suitable for:

Very sensitive, dry or irritated skin
Pregnancy and breastfeeding
Known incompatibility against retinoides or benzoyl peroxide

Available Dosages

Concentration of active substance:

Adapalen: 1 mg/g (0.1%)
Benzoyl peroxide: 25 mg/g (2.5%)

Varians:

Epiduo Gel: Adapalen 0.1% + benzoyl peroxide 2.5%
Epiduo Forte: Adapalen 0.3% + benzoyl peroxide 2.5%

Pack sizes:

15 g tube
30 g tube
45 g tube (cont'd)
60 g tube

How to Take

Application: 1. skin with mild, non-seifiable cleaner wash Two. Let dry (important!) 3. Apply a thin layer once a day in the evening 4. Apply to the entire area Five. Wash hands thoroughly after application

Time: Apply once a day. Adapals can make light-sensitive, so evening use is important.

Reconciliation phase: In the first 2-4 weeks, increased dryness, redness and dandruff can occur. This is normal and usually leaves. In case of severe irritation, apply every second day.

Important notes:

Sun protection per day is mandatory (LSF 30+)
Avoid contact with eyes, lips and mucous membranes
Use benzoyl peroxide bleached textiles – white towels and pillowcases
No wax dehairing in the treated area

Contraindications

**Epiduo may not be used at:* *

hypersensitivity to adapals, benzoyl peroxide or auxiliary substances
Pregnancy (retinoids can damage the unborn child)
eczema, sunburn or irritated skin
Rosacea or perioral dermatitis

Preview at:

Still time (only after consultation, do not apply in the breast area)
Very sensitive skin
Simultaneous application of other irritating skin products

Important: Females with a birthable age must use safe prevention during treatment.

Possible Side Effects

Very common (>10%):

dry skin
dandruff
Skin redness (erythem)
Burn or steal

Acid (1-10%):

Itching
Contact dermatitis
Skin irritation
Aggravation of acne at the beginning

Occasionally:

Sunburn-like reactions
Allergic reactions
Swelling

Measurement: In the first weeks, the acne can get worse for a short time before a recovery occurs. This is normal.

Tips for side effects:

Use non-comedogenic moisturizer
In case of severe irritation apply only every 2nd day
Use mild cleaning products

Interactions

Do not apply at the same time:

Other retinoides (topic or systemic)
Strong drying or irritating products
Products with high alcohol content
Sulfur-containing acne products

Preview at:

AHA/BHA-Peeelings – enhanced irritation
Physical Peelings (Scrubs)
Other topical acnetics

Recommendation: If necessary, additionally use a mild moisturizer. Other active products with the doctor.

Frequently Asked Questions

Similar Medications

Differin

Duac Akne Gel

Skinoren

Acnatac

Is epiduo right for you?

A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.

Important Notice

This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.

Important Safety Information

This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.