Sildenafil 1A Pharma

Sildenafil 1A Pharma is a generic of the PDE-5 inhibitor sildenafil.

1A Pharma is part of the Hexal group and stands for high-quality generics.

Identical to other sildenafil products: PDE-5 inhibition leads to an improved erection during sexual stimulation.

Men with erectile dysfunction.

25 mg, 50 mg, 100 mg

30-60 minutes before sex, no more than once a day.

You must not take Sildenafil 1A Pharma in the following cases:

• Use of nitrates of any kind or nitric oxide donors (e.g. amyl nitrite) – sildenafil increases their blood-pressure-lowering effect
• Use of guanylate cyclase stimulators such as riociguat – possible drop in blood pressure with symptoms
• Conditions in which sexual activity is inadvisable for you, e.g. severe cardiovascular disease such as unstable angina pectoris or severe heart failure
• Recent stroke or heart attack
• Low blood pressure (below 90/50 mmHg)
• Severe hepatic impairment
• Loss of vision in one eye due to NAION (non-arteritic anterior ischaemic optic neuropathy), regardless of whether the loss of vision was related to previous use of a PDE-5 inhibitor
• Hereditary degenerative retinal disorders such as retinitis pigmentosa
• Hypersensitivity to sildenafil or any of the other ingredients

Very common (at least 1 in 10 patients):

• Headache

Common (1 to fewer than 10 in 100 patients):

• Facial redness (flushing), hot flushes
• Stuffy nose
• Dizziness
• Nausea, indigestion (dyspepsia)
• Visual disturbances, changes in colour vision, blurred vision

Rare (1 to fewer than 10 in 10,000 patients):

• Heart attack, unstable angina pectoris, heart rhythm disorders, sudden cardiac death
• Stroke, seizures
• Damage to the optic nerve due to reduced blood flow (NAION), blockage of a retinal blood vessel
• Deafness
• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Prolonged erection or priapism: If an erection lasts longer than 4 hours, seek medical help immediately.

Other side effects can occur uncommonly or rarely.

If you experience a sudden visual disturbance of any kind, stop taking Sildenafil 1A Pharma and see a doctor immediately.

Do not use at the same time:

• Nitrates of any kind and nitric oxide donors (e.g. amyl nitrite): sildenafil enhances their blood-pressure-lowering effect; concomitant use is contraindicated.
• Riociguat: concomitant use with sildenafil is contraindicated, as blood pressure may drop further.
• Nicorandil: because of its nitrate component, a serious interaction with sildenafil is possible.

Not recommended or use with caution:

• Ritonavir: concomitant use is not advised. In any case, the sildenafil dose must not exceed 25 mg within 48 hours.
• Other CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, erythromycin, saquinavir, cimetidine): they increase sildenafil levels in the blood; a starting dose of 25 mg should be considered. Grapefruit juice can slightly increase the level.
• Alpha blockers (e.g. doxazosin): in a small number of susceptible people, a drop in blood pressure with symptoms can occur, most likely within 4 hours of taking the medicine. Before starting, you should be stabilized on the alpha blocker; a starting dose of 25 mg should be considered.
• Sacubitril/valsartan: greater lowering of blood pressure; caution when starting treatment with sildenafil.
• Strong CYP3A4 inducers (e.g. rifampicin): they can markedly reduce sildenafil levels.
• Other PDE-5 inhibitors or other treatments for erectile dysfunction: the combination is not recommended.