What is Avamys® (Fluticasonfuroate)?
Avamys® is a nasal corticosteroid spray with the active ingredient Fluticasonfuroat. It is one of the most effective treatments for allergic rhinitis and is considered as a gold standard for moderate to severe hay fever.
Fluticasonfuroate is a newer corticosteroid with a particularly high binding affinity to the glucocorticoid receptor and a very low systemic absorption. This means: strong local effect in the nose with minimal side effects in the rest of the body.
Avamys® is also characterized by a pleasant spray profile – the fine spray mist is evenly distributed in the nose and causes less irritation than other nasal sprays.
Active Ingredients & Mechanism of Action
Active ingredient: Fluticasonfuroat
Fluticasonfuroate acts as a strong anti-inflammatory corticosteroid in the nasal mucosa:
Active mechanism:
- Ties to the glucocorticoid receptor in the cells of the nasal mucosa
- Inhibits the release of inflammatory mediators (prostaglandins, leukotrienes, cytokines)
- Reduces the immigration of inflammatory cells (eosinophiles, mast cells, lymphocytes)
- Reduces swelling of the nasal mucosa
Activation of symptoms:
- Blocked nose (main advantage over antihistamines)
- Nostrils
- Nope
- Itching
- Also eye symptoms are often improved (naso-ocular reflex)
Initiation of action: A noticeable improvement often occurs after 8 hours. The full effect develops over several days of regular application.
Who is it suitable for?
Avamys® is suitable for:
- Adults and young people from 12 years old with allergic rhinitis
- Children from 6 years (under medical supervision)
- Seasonal and perennial allergic rhinitis
- Moderate to severe symptoms, especially nasal constipation
Especially recommended at:
- Blocked nose as main symptoms (antihistamines are weaker here)
- Inadequate effect of oral antihistamines alone
- Combination with oral antihistamines in severe symptoms
- Long-term treatment of perennial allergies
Not suitable:
- Acute nasal sinus infection (not without medical treatment)
- Nose bleeding or nasal injuries
- After nose surgery (until complete healing)
Available Dosages
Adults and young people aged 12:
- Start dose: 2 spray taps per nostril once a day (= 55 μg × 2 = 110 μg total)
- Maintenance dose for symptom control: 1 spray per nostril once a day (55 μg total)
Children 6-11 years:
- 1 spray per nostril once a day (55 μg total)
- In case of insufficient control: 2 spray taps per nostril (medical control)
Available strength:
- 27.5 μg Fluticasonfuroate per spray jet (120 spray jets per bottle)
Application duration:
- Seasonal: throughout the pollen season
- Ideally start 1–2 weeks before pollen start
- Perennial: All year possible under medical control
How to Take
Application:
- Nose gently sneaking before use
- Shake a bottle
- Insert spray opening into the nose hole, slightly inclined to the outside
- Gently breathe through the nose during spraying
- Do not spray the nose
Important notes:
- Apply once a day, always at the same time
- Regular application is crucial - not only if necessary
- Pre-application: Spray head 6 times pump (priming)
- After 30 days Non-use: Renewed primen
- Clean spray head regularly
Quality:
- Do not put the head in the neck
- Spray easily directed away from the nasal wall
- Don't sneak at the same time - gently breathing
Contraindications
**Avamys® must not be used at:* *
- hypersensitivity to Fluticasonfuroate or any of the other components
Preview at:
- Heavy liver failure (increased systemic exposure)
- Simultaneous treatment with Ritonavir or other strong CYP3A4 inhibitors (increased cortisol suppression)
- Active or latent tuberculosis
- Untreated fungal infection of the nose
- Recent nose surgery or nose injury
- children (long-term use under medical control due to growth)
pregnant and breastfeeding: Should only be applied after strict use-risk weighing. Systemic admission is minimal, yet medical consultation is recommended.
Possible Side Effects
Family (1–10 %):
- Nose bleeding (Epistaxis) – most common side effect
- ulcer of the nasal mucosa
** Occasionally (0.1-1 %):* *
- Headaches
- Nose pain or discomfort
- Nasent dryness
Selten:
- hypersensitivity reactions (Urtikaria, Angioedema)
- Anaphylaxis (extremely rare)
- Nose septumperforation (for long-term use, very rare)
Systemic side effects: Systemic cortisone effects (weight increase, osteoporosis) are not to be expected when used as intended, since the systemic bioavailability of Fluticasonfuroat nasal is less than 0.5%.
** Nose bleeding occurs more frequently when the spray is sprayed directly onto the nostril wall. Proper application technology significantly reduces this risk.
Interactions
Preview with simultaneous use of:
- Ritonavir and other strong CYP3A4 inhibitors (increasing systemic floodicason exposure, cushing risk)
- Ketoconazole, Itraconazole (similar mechanism)
- Other nasal or inhalative corticosteroids (additive cortisol suppression)
No relevant interaction with:
- Oral antihistamines (safe and recommended combination)
- leukotriene antagonists
- Swelling nasal sprays (short time)
** The combination of Avamys® with an oral antihistaminic agent (e.g. Desloratadin) is standard therapy for moderate to severe symptoms.
Frequently Asked Questions
Similar Medications
Is Avamys® (Fluticasonfuroate) right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.