What is Clotrimazole?
Clotrimazole is a broad-spectrum antifungal for the local treatment of fungal infections. It is used for vaginal yeast infections and is also suitable for other fungal skin conditions.
For the treatment of vaginal yeast infections, clotrimazole is available as vaginal tablets (ovules), vaginal cream, and as a combination with cream for the external area. Local application has the advantage that hardly any active ingredient enters the bloodstream.
Well-known brand names are Canesten® and numerous generics.
Active Ingredients & Mechanism of Action
Active ingredient: Clotrimazol
Clotrimazole disrupts the fungal cell membrane:
Mechanism of action:
- Inhibits ergosterol synthesis in fungal cells
- Without ergosterol, the fungal membrane becomes permeable
- The fungal cells die (fungicidal) or are prevented from growing (fungistatic)
Spectrum of activity:
- Candida species (incl. Candida albicans)
- Dermatophytes
- Molds
- Yeasts
Local action: When used vaginally, clotrimazole acts directly at the site of infection. Systemic absorption is minimal.
Who is it suitable for?
Clotrimazole is suitable for:
- Acute vaginal yeast infection
- Vulvovaginal candidiasis
- Supportive therapy alongside oral treatment
- Pregnancy (preferred treatment)
Advantages:
- Local action without systemic burden
- Can be used during pregnancy
- Also for the external genital area
Not suitable for:
- Bacterial infections
- If the diagnosis is uncertain
Available Dosages
Vaginal tablets:
- 100 mg (6 days)
- 200 mg (3 days)
- 500 mg (1 day, single dose)
Vaginal cream:
- 1% or 2%
- Usually 5 g once daily for 3-6 days
Combination packs:
- Vaginal tablets + cream for external use
Recommendation: For acute vaginal yeast infection: 500 mg vaginal tablet as a single dose or 200 mg for 3 days.
Dosage form and pack sizes
The medicines catalogue lists one pack variant: one strength in one pack size.
- Dosage form
- Vaginaltablette
- Strengths
- 200 mg
- Pack sizes
- 3 units
| Strength | Pack | PZN | Duration |
|---|---|---|---|
| 200 mg | 3 units | 03630859 | 0 days |
Packs listed in the German medicines catalogue. Which of them are currently available and what they cost is shown in the price overview.
The Pharmazentralnummer (PZN) is the nationwide unique identifier of a pack in Germany.
Duration is the catalogue value for the usual dosage. How long a pack actually lasts depends on the dose your doctor prescribes.
How to Take
Vaginal tablets: 1. Insert in the evening before going to bed 2. Insert deep into the vagina (applicator or finger) 3. Preferably while lying down 4. No tampons during treatment
Vaginal cream:
- Insert deep into the vagina with the applicator
- Apply in the evening
- Apply external cream to the vulva
General notes:
- If possible, do not carry out the treatment during menstruation, but complete it before menstruation begins
- Complete the full treatment duration even if symptoms improve
- Wear cotton underwear
- If your partner has symptoms, have them treated as well
Contraindications
Clotrimazole must not be used in cases of:
- Hypersensitivity to clotrimazole or other azoles
Use with caution in cases of:
- First occurrence of a vaginal yeast infection (consult a doctor)
- Symptoms that do not match a vaginal yeast infection
- Frequently recurring infections
Pregnancy: Clotrimazole is the treatment of choice for vaginal yeast infections during pregnancy. During pregnancy, use vaginal tablets and insert them without an applicator.
Breastfeeding: Can be used. Local application, minimal systemic absorption.
Possible Side Effects
Frequency not known:
- Burning
- Itching
- Redness
- Discharge
- Allergic reactions
- Swelling
- Skin rash
- Hypersensitivity reactions
Note: Mild burning at the start of treatment is normal and not a reason to stop using it. If symptoms are severe, see a doctor.
Interactions
No systemic interactions with vaginal/topical use.
May impair:
- Latex condoms and diaphragms – effectiveness may be reduced!
- Use alternative contraception during treatment
Can be combined with:
- Oral antifungals (fluconazole) for persistent infections
Frequently Asked Questions
With the single dose (500 mg), one application. With 200 mg: 3 days, with 100 mg: 6 days. Symptoms usually improve after 1-2 days, but the full treatment duration should be completed.
Better not. The cream can damage condoms, and the active ingredient can irritate your partner. Wait until the end of treatment.
Yes, clotrimazole is the preferred treatment for vaginal yeast infections during pregnancy. Local application is safe. During pregnancy, vaginal tablets should be used and inserted without an applicator.
Mild burning is normal, especially if the mucous membrane is already irritated. It should subside after a few minutes. If the burning is severe or persistent, stop treatment and see a doctor.
Similar Medications
Is Clotrimazole right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.