What is Canemes?
Canemes is a medicine containing the active ingredient nabilone, a synthetic cannabinoid. It is structurally related to THC and acts in a similar way via the endocannabinoid system.
In Germany, Canemes is approved for the treatment of nausea and vomiting associated with chemotherapy when other antiemetics are not sufficiently effective.
It offers standardized dosing in capsule form and is classified as a prescription-only narcotic.
Active Ingredients & Mechanism of Action
Active ingredient: Nabilon (synthetisches Cannabinoid)
Nabilone acts via the endocannabinoid system:
Mechanism of action:
- Agonist at CB1 and CB2 receptors
- Inhibits the vomiting center in the brain
- Modulates pain perception
Effects:
- Strongly antiemetic (against nausea)
- Mildly pain-relieving
- Appetite-stimulating
- Anxiolytic (anxiety-relieving)
Pharmacokinetics:
- Good oral bioavailability
- Onset of action: 1-2 hours
- Duration of action: 8-12 hours
Who is it suitable for?
Canemes is approved for:
- Nausea and vomiting caused by chemotherapy (when standard antiemetics fail)
Requirements:
- Other antiemetics not sufficiently effective
- Prescription by a doctor on a BtM prescription
Not suitable:
- In severe psychiatric illnesses
- During pregnancy and breastfeeding
- Under 18 years of age
Available Dosages
Available strength:
- 1 mg capsules
Dosage during chemotherapy:
- 1-2 mg twice daily
- First dose on the evening before chemotherapy
- Continue during chemotherapy
- Until 48 hours after the last chemotherapy dose
Maximum dose:
- 6 mg daily, divided into 3 single doses
Important: Individual dose adjustment under medical supervision.
How to Take
How to take:
- Swallow the capsules whole with water
- Can be taken with or without meals
- First dose on the evening before chemotherapy
Notes:
- BtM prescription required
- No driving or operating machinery
- No alcohol
- Regular medical check-ups
Contraindications
Contraindications:
- Hypersensitivity to nabilone or cannabinoids
- Severe mental illness
- Pregnancy and breastfeeding
Use with caution in:
- Cardiovascular disease
- Liver disease
- History of addictive disorders
- Elderly patients
Possible Side Effects
Common:
- Dizziness
- Drowsiness
- Dry mouth
- Euphoria
- Difficulty concentrating
- Visual disturbances
- Low blood pressure
- Low mood (dysphoria)
Rare:
- Rapid heartbeat
- Loss of appetite
- Hallucinations
- Psychoses
- Depression
Interactions
Interactions with:
- CNS depressants (benzodiazepines, opioids)
- Alcohol
- Anticholinergics
Fitness to drive:
- Canemes can impair the ability to drive and use machines
- The effect can last for a variable and unpredictable length of time
- Psychological side effects can persist for 48 to 72 hours after the end of treatment
Frequently Asked Questions
Canemes contains nabilone (a synthetic cannabinoid), while dronabinol contains synthetic THC. Nabilone has a longer duration of action and is only approved for nausea and vomiting associated with chemotherapy when other antiemetics are not sufficiently effective.
Yes, Canemes is a narcotic and requires a BtM prescription on a special form.
The effect lasts 8-12 hours. The first dose should be taken on the evening before chemotherapy.
Similar Medications
Is Canemes right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.