What is Mysimba?
Mysimba is an oral drug for weight reduction that combines two active ingredients: Naltrexon (an opioid antagonist) and Bupropion (an antidepressant/smoothing agent).
Unlike the GLP-1 agonists (Wegovy, Ozempic), mysimba acts primarily in the brain on the reward and saturation center. It is taken as a tablet, not sprayed.
Mysimba is approved for adults with BMI ≥ 30 or BMI ≥ 27 with accompanying diseases.
Active Ingredients & Mechanism of Action
Active ingredient: Naltrexon 8 mg, Bupropion 90 mg
The combination has a synergistic effect on the brain:
Bupropion:
- Inhibition of dopamine and norepinephrine
- Stimulates neurons in the hypothalamus that regulate appetite
- Reduces the desire for food
Naltrexon:
- Blocks Opioid receptors
- Strengthens and extends the action of Bupropion
- Reduces the feeling of reward when eating
Call:
- Reduced appetite
- Reduced desire for food (especially "emotional eating")
- Increased energy consumption
Who is it suitable for?
Mysimba is suitable for:
- Adults with BMI ≥ 30 (obesity)
- Adults with BMI ≥ 27 and at least one weight-related accompanying disease
- People who have difficulties with emotional food
- As an alternative to injectable drugs
Not suitable for uncontrolled hypertension, epilepsy, eating disorders.
Available Dosages
Stepwise dose increase:
- Week 1: 1 tablet in the morning
- Week 2: 1 tablet in the morning + 1 evening
- Week 3: 2 tablets in the morning + 1 evening
- From week 4: 2 tablets in the morning + 2 in the evening (maintenance dose)
Maximaldosis: 4 tablets daily (2-0-2)
How to Take
- Swallow pills with water
- Preferably at meals
- Not with high-fat meal (increase risk)
- Dosage increase as prescribed
Contraindications
Absolute contraindications:
- Uncontrolled high blood pressure
- Epilepsy or seizures in prehistory
- tumor of the central nervous system
- alcohol or benzodiazepine withdrawal
- Bulimia or Anorexia
- Simultaneous intake of MAO inhibitors
- Opioid intake or withdrawal
- Heavy liver failure
Relative contraindications:
- Bipolar disturbance
- Heavy depression
- Kidney failure
Possible Side Effects
Very common:
- nausea
- Blocking
- Headaches
- Break.
**
- Squeeze
- Mouth dryness
- Sleep disorders
- Fear, irritability
- Blood pressure increase
- stomach pain
Selten, but seriously:
- seizures (risk increases with rapid dose increase)
- Suicidal thoughts (monitoring in psychiatric history)
Interactions
Contracted:
- MAO inhibitor (14 days distance)
- Opioide (Naltrexon blocks its effect!)
- Other Bupropionic preparations
Preview:
- Blood pressure-enhancing drugs
- medicines that lower the cramp threshold
- CYP2D6 substrates (tamoxifen, metoprolol)
Frequently Asked Questions
Similar Medications
Is Mysimba right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.