What is Mounjaro?
Mounjaro is a new drug from Eli Lilly with the active ingredient Tirzepatid. It is the first approved dual agonist that simulates two intestinal hormones simultaneously: GLP-1 and GIP.
What makes Mounjaro special: Unlike Ozempic or Wegovy, which only imitate GLP-1, Tirzepatid acts on two hormone receptors. This leads to a stronger effect on weight and blood sugar.
Current approval:
- Approved for type 2 diabetes in the EU
- Approved for weight reduction (under the name Zepbound) in the USA
- EU approval for obesity is expected
Study results: In the SURMOUNT study, participants lost an average of 20-22% of their body weight – more than any other approved drug.
Active Ingredients & Mechanism of Action
Active ingredient: Tirzepatid
Tirzepatid is a dual agonist that imitates two incense hormones:
GLP-1 action:
- Enhanced saturation
- Slowed gastric emptying
- Improved insulin secretion
GIP action:
- Additional appetite suppression
- Improved fat metabolism
- Synergistic effect with GLP 1
**The combination leads to:* *
- Stronger appetite reduction as pure GLP-1 agonists
- Higher weight loss
- Better blood sugar control
- Improved fat metabolism
SURMOUNT study results:
- 15 mg: Average 22.5% weight loss
- 10 mg: Average 21.4% weight loss
- 5 mg: Average weight loss 16.0%
Who is it suitable for?
Current approval (EU):
- Type 2 diabetes mellitus in adults
- In combination with diet and exercise
Expected approval for obesity:
- BMI ≥ 30 or
- BMI ≥ 27 with accompanying disease
Specially promising for:
- High weight loss patients
- If other GLP-1 agonists do not work enough
- In combination of diabetes and obesity
Not suitable for:
- Type 1 diabetes
- Pancreatitis in prehistory
- Medulle thyroid cancer
- Pregnancy
Available Dosages
dosing scheme:
- Weeks 1-4: 2.5 mg weekly
- Weeks 5-8: 5 mg weekly
- Weeks 9-12: 7.5 mg weekly (optional)
- Weeks 13-16: 10 mg weekly (optional)
- From week 17: 12.5 or 15 mg weekly (optional)
Content boxes:
- 5 mg, 10 mg or 15 mg depending on the effect and compatibility
- Maximum dose: 15 mg once a week
** The dose is individually adjusted. Not everyone needs the maximum dose.
How to Take
Application:
- One week, the same weekday
- Subcutaneous injection
- belly, thigh or upper arm
- Independent meals
Pre-filled pen:
- One-time pens per dose
- Easy handling
- Needle already integrated
Change weekday: Possible if at least 3 days have passed since the last injection.
Restoration:
- In the refrigerator (2-8°C)
- Can be stored once for 21 days at room temperature
Contraindications
Contraindications:
- hypersensitivity to Tirzepatid
- Medulläres thyroid carcinoma (or family history)
- MEN 2 (Multiple endocrine neoplasia type 2)
- Heavy gastrointestinal diseases
Preview at:
- Pancreatitis in prehistory
- Diabetic retinopathy
- Gallensteinleiden
- Heavy kidney or liver failure
pregnant:
- Cancel at least 2 months before planned pregnancy
Possible Side Effects
Very common (>10%):
- nausea
- diarrhea
- Blocking
- Break.
- stomach pain
- Reduced appetite
Acid (1-10%):
- Sodburning
- Blowing
- Repulse
- fatigue
- Hypoglycemia (in diabetics)
- Reactions at the injection site
Occasionally:
- gallstones
- Increased heart rate
- Hair loss
Selten, but seriously:
- Pancreatitis
- Heavy allergic reactions
- Deterioration of diabetic retinopathy
** GI side effects are common at the beginning, but usually improve. Slow dosing helps.
Interactions
Insulin and sulfonylureas:
- Increased hypoglycemia risk
- Dose reduction of these medications necessary
Oral contraceptives:
- Reduced recording possible
- Additional prevention in GI complaints
Oral medicines in general:
- Delayed intake due to slower gastric emptying
Frequently Asked Questions
Similar Medications
Is Mounjaro right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.