Nadixa

Nadixa is a prescription-only cream containing the active ingredient nadifloxacin, a topical fluoroquinolone antibiotic. It is used to treat inflammatory acne vulgaris.

Nadifloxacin has a bactericidal effect against the acne-causing bacteria Cutibacterium acnes (formerly Propionibacterium acnes) and other skin germs. Unlike erythromycin or clindamycin, nadifloxacin shows less development of resistance.

The cream is applied to the affected areas of skin 2x daily and is approved for adults and adolescents aged 14 years and older.

Nadifloxacin acts as a gyrase inhibitor:

Mechanism of action:

• Inhibits bacterial DNA gyrase (topoisomerase II)
• Prevents DNA replication in bacteria
• Bactericidal effect against Cutibacterium acnes
• Additional effect against Staphylococcus aureus

Advantages:

• Low resistance rate compared with erythromycin/clindamycin
• Broad antibacterial spectrum
• Local application only (low systemic absorption)

Time course:

• First improvement: after 2-4 weeks
• Optimal effect: after 4-8 weeks of regular use

Nadixa is suitable for:

• Mild to moderate inflammatory acne vulgaris
• Papulopustular acne
• Adults and adolescents aged 14 years and older

Advantages:

• Alternative in cases of resistance to erythromycin/clindamycin
• Less development of resistance
• Well tolerated

Not suitable:

• Severe nodular or cystic acne (systemic therapy required)
• Children under 14 years of age
• Comedones only (non-inflammatory acne)

Nadixa Cream 1%:

• Apply a thin layer to the affected areas of skin 2x daily
• In the morning and evening after cleansing
• Duration of treatment: usually 4-8 weeks

Note: Do not use for longer than 8 weeks.

Application: 1. Cleanse and dry the face thoroughly 2. Apply a thin layer of Nadixa to the inflamed areas 3. Gently massage in 4. Wash your hands 5. 2x daily (morning and evening)

Important:

• Avoid contact with the eyes, mouth, and mucous membranes
• If skin irritation occurs, reduce or pause application
• Use sun protection

Do not use in case of:

• Hypersensitivity to nadifloxacin or other quinolones
• Children under 14 years of age

Caution in case of:

• Sensitive skin
• Simultaneous UV exposure (photosensitization possible)

Pregnancy: Not recommended. Insufficient data.

Breastfeeding: Not recommended.

Common (1-10%):

• Itching

Uncommon:

• Dry skin
• Skin irritation, redness, skin rash
• Burning at the application site, feeling of warmth
• Papules
• Contact dermatitis
• Episodes of skin reddening with a feeling of heat (flushing)

Rare:

• Hives (urticaria)

Interactions:

• No clinically relevant interactions are known with topical use

Can be combined with:

• Benzoyl peroxide (applied at different times)
• Retinoids (applied at different times, e.g., retinoid in the evening, Nadixa in the morning)