What is lansoprazole?
Lansoprazole is a proton pump inhibitor (PPI) for the treatment of sodburns, gastroesophageal reflux disease (GERD) and gastrointestinal/intestinal ulcers. It is available under the brand name Agopton® and as a generic.
Lansoprazole is characterized by a somewhat faster impact than other PPIs. It is available as a capsule and as a melt tablet (orodispersible), which makes it easier to take with swallowing problems.
Like all PPIs, Lansoprazol inhibits gastric acid production and is used for short and long-term treatment of acid-related diseases.
Active Ingredients & Mechanism of Action
Active ingredient: Lansoprazol
Lansoprazole irreversibly inhibits the proton pump of the gastric insert cells:
Active mechanism:
- Prodrug, activated in the acid medium of the document cell
- Irreversible binding to H+/K+-ATPase
- Blocks acid production in the last step
- Reduction of gastric acid by up to 90%
Special features:
- A little faster than omeprazole
- High bioavailability
- half-life approx. 1-2 hours, but working time 24+ hours
Who is it suitable for?
Lansoprazole is suitable for:
- Gastroesophageal reflux disease (GERD)
- Refluxeophagitis
- Gastrointestinal ulcers
- Helicobacter-pylori-Eradikation
- Gastric protection at NSAID intake
- Zollinger-Ellison Syndrome
- Patients with swallowing complaints (melting tablet available)
Not suitable:
- In case of unclear structural problems without diagnosis
- As long-term therapy without medical indication
Available Dosages
Available starches:
- 15 mg capsules/melt tablets
- 30 mg capsules/melt tablets
Other dosages:
- Sodburning/light reflux: 15-30 mg 1x daily
- Refluxesophagitis: 30 mg 1x daily for 4-8 weeks
- Gastric ulcer: 30 mg 1x daily for 4 weeks
- 12-fingered ulcer: 30 mg 1x daily for 2-4 weeks
- Helicobacter Eradication: 30 mg 2x daily (with antibiotics)
- Maintenance: 15 mg 1x per day
How to Take
Intake:
- Morning, 30 minutes before breakfast
- Capsules unzerkaut swallow
Small tablet (FasTab):
- Put on the tongue and disintegrate
- Removable without water
- Ideal for slippers
**
- Regularly take, not only in case of complaints
- Do not drop abruptly after long-term therapy
- Regular medical check for permanent use
Contraindications
**Lansoprazole must not be taken at:* *
- hypersensitivity to lansoprazole or other PPIs
- Simultaneous intake of Atazanavir or Nelfinavir
Preview at:
- liver failure (max. 30 mg, monitor liver values)
- Long-term application (standard risks of PPI class)
- Suspicion of stomach cancer
Pregnant period: Only with urgent indication. Limited data.
Possible Side Effects
Acid (1-10%):
- Headaches
- Squeeze
- diarrhea
- nausea
- stomach pain
- Blocking
- Blowing
Occasionally:
- Skin rash
- Mouth dryness
- joint pain
- fatigue
Long-term risks (all PPIs):
- Magnesium deficiency
- Vitamin B12 deficiency
- Increased fracture risk
- Clostridium difficile infection risk
Interactions
Reduced absorption by pH increase:
- Ketoconazole, Itraconazole
- Iron preparations, vitamin B12
- Atazanavir, Nelfinavir (contrained)
Lansoprazole inhibits CYP2C19 (moderate):
- Interaction potential between omeprazole and pantoprazole
- Caution in Clopidogrel (Pantoprazole may prefer)
Theophyllin: Accelerated elimination possible. Control mirrors.
Frequently Asked Questions
Similar Medications
Is lansoprazole right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.