What is rizatriptan?
Rizatriptan is a modern triptan for the treatment of acute migraine attacks. It is distinguished by rapid action and is especially available as a melt tablet which can be taken without water.
Rapid action (within 30 minutes) makes Rizatriptan a good choice when rapid relief is required. The melt tablet is also advantageous in case of nausea or if no water is available.
The known brand name is Maxalt®.
Active Ingredients & Mechanism of Action
Active ingredient: Rizatriptan
Rizatriptan acts on the same mechanism as other triptans:
Active mechanism:
- Activation of 5-HT1B/1D serotonin receptors
- constriction of extended cranial blood vessels
- Inhibition of the release of vasoactive peptides (CGRP)
- Blocking the trigeminal pain transfer
Special features:
- Fast action: 30 minutes
- High lipophilia – good CNS capability
- Melt tablet dissolves in seconds
Activity: The effect lasts about 24 hours. When the headache is returned, a second dose can be taken after 2 hours.
Who is it suitable for?
Rizatriptan is suitable for:
- Adults with acute migraine attacks
- Patients who need rapid action
- In case of nausea / vomiting (melting tablet)
- If no water is available
Special advantage:
- For severe migraine-related nausea
- For traveling
- On early intervention in the attack
Not suitable for:
- cardiovascular diseases
- Uncontrolled high blood pressure
- Propranolol therapy (dose reduction required!)
- Hemiplegic or Basilaris marshes
Available Dosages
Tablets:
- 5 mg
- 10 mg (standard dose)
Melt tablets (Maxalt lingua):
- 5 mg
- 10 mg
Recommended dosage:
- Adults: 10 mg at the start of attack
- If required, second dose after 2 hours
- Maximum: 20 mg in 24 hours
For Propranolol intake:
- Only 5 mg Rizatriptan (half dose!)
How to Take
Normal tablets:
- Suck with water
- At the start of headache, not at Aura
melting tablets:
- Put on the tongue
- Releases in seconds
- Swallow with saliva
- No water needed
Time:
- Taking first headaches
- Early intake is more effective
- Not during the aura phase
If first dose does not work: No second dose for the same attack. Try again at the next attack.
Contraindications
**Rizatriptan must not be taken at:* *
- coronary heart disease
- condition after heart attack, stroke, TIA
- Heavy or uncontrolled hypertension
- Peripheral arterial disease
- Heavy liver or kidney failure
- Hemiplegic or Basilaris marshes
- MAO inhibitor therapy (or < 2 weeks thereafter)
- Simultaneous ergotamine intake
Preview at:
- Propranolol therapy (half dose!)
- Cardiovascular risk factors
- Easier/medium liver / kidney failure
Possible Side Effects
Acid (1-10%):
- Squeeze
- Bemonia
- fatigue
- Asthenie (smooth)
- nausea
Triptane-specific sensations:
- Crawling, numbness
- Heat or cold feeling
- Pressure or constriction (breast, neck)
- Heavy in limbs
Occasionally:
- Heart palp
- Mouth dryness
- diarrhea
Selten:
- Allergic reactions
- Coronary seeds
- serotonin syndrome
Note to melt tablets: Can contain aspartame – Be careful with phenylketonuria.
Interactions
Important – Propranolol:
- Rizatriptan mirror rising to double
- Only 5 mg of rizatriptan with simultaneous propanolol intake!
Not combine with:
- ergotamine (24 hours distance)
- Other triptans on the same day
- MAO inhibitors
Preview at:
- SSRI/SNRI (Serotoninsyndrom risk)
- St. John's wort
- Lithium
Frequently Asked Questions
Similar Medications
Is rizatriptan right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.