Ovestin

Ovestin contains estriol, a weak natural estrogen that is applied locally in the vaginal area. It is used to treat symptoms caused by estrogen deficiency in the intimate area – often after menopause.

Ovestin is available as a vaginal cream and as vaginal suppositories (Ovula). Because estriol acts only locally and barely enters the bloodstream, it has significantly fewer systemic side effects than oral hormone replacement therapies.

Estriol:

• Is one of the three natural estrogens (alongside estradiol and estrone)
• Acts more weakly and for a shorter time than estradiol
• Is absorbed by the vaginal tissue and acts locally

Effects:

• Improved blood flow to the mucosa
• Normalization of vaginal pH
• Rebuilding of the vaginal mucosa
• Improved elasticity

Ovestin is suitable for:

• Vaginal dryness after menopause
• Pain during intercourse due to estrogen deficiency
• Recurrent urinary tract infections due to atrophic mucosa
• Itching and burning in the intimate area
• Before/after gynecological procedures

Often also possible for women with contraindications to systemic HRT.

Ovestin Cream:

• 1 mg estriol per gram of cream
• Can be dosed with the applicator

Ovestin Ovula:

• 0.5 mg estriol per suppository

Dosage:

• Initial: 1x daily for 2-3 weeks
• Maintenance: 2x weekly

Cream:

• Insert into the vagina using the applicator
• In the evening before going to bed
• Clean the applicator after use

Suppositories:

• Insert deep into the vagina
• Use in the evening
• Panty liner recommended

Absolute contraindications:

• Current or previous breast cancer, or suspected breast cancer
• Estrogen-dependent tumors
• Unexplained vaginal bleeding
• Acute thromboembolism
• Severe liver disease

Relative contraindications:

• Previous thrombosis
• Endometriosis
• Fibroids

Local (common at first):

• Mild burning on application
• Increased discharge
• Itching

Rare:

• Breast tenderness
• Nausea
• Headache

Systemic side effects are very rare with local use.

Caution with:

• Enzyme inducers such as rifampicin, carbamazepine, phenytoin or phenobarbital – they speed up the breakdown of estriol and can weaken its effect
• St. John's wort preparations – same effect; herbal remedies are relevant here too

With vaginal use: Cream and suppositories enter the bloodstream only to a small extent, so interactions are less likely than with tablets. The cream base can impair the tear resistance of latex condoms and diaphragms.

Important: Tell your doctor about all medicines you take, including herbal and non-prescription ones.