What is Estramon conti?
Estramon conti is a combined transdermal plaster that releases both estradiol (estrogen) and norethisterone acetate (stagnation) over the skin. It is used for the treatment of alternating-year complaints in postmenopausal women with intact uterus.
The great advantage of the patch: both hormones are absorbed via the skin and bypass the liver (no first pass effect). This leads to a lower risk of thrombosis than in oral preparations and a more uniform release of hormones.
The plaster is changed 2x per week and is designed as a continuous combination therapy (bleed-free).
Active Ingredients & Mechanism of Action
Active ingredient: Estradiol 50 µg/24h, Norethisteronacetat 170 µg/24h
Transdermal hormone charge over 3-4 days:
Estradiol:
- Is absorbed into the blood circulation via the skin
- equals the oestrogen deficiency
- Relieves heat flashes and sweat breaks
- Improves vaginal health
Norethisterone acetate:
- Protects the cervical mucosa
- Prevents endometrium hyperplasia
- Continuous delivery = no bleeding
Advantages of transdermal administration:
- Resurrection of the liver
- Lower risk of thrombosis
- Uniform hormone levels
- Less influence on blood fats and coagulation factors
Who is it suitable for?
Estramon conti is suitable for:
- Postmenopausal women (last bleeding > 12 months)
- Women with intact uterus
- Women with increased risk of thrombosis (perversely preferred)
- Women who want to avoid tablets
Advantages:
- Change only 2x per week
- bleeding-free
- Lower risk of thrombosis as tablets
- Both hormones in a plaster
Not suitable:
- In contraindications against HRT
- Incompatibility with plaster
- Perimenopausal women
Available Dosages
Estramon conti patch:
- Estradiol 50 μg/24h + NETA 170 μg/24h
- 1 patch every 3-4 days (2x per week)
- Throughout without a break
Plant change days:
- Choose festive days (e.g. Monday and Thursday)
- Always change the same day
How to Take
Pflaster on glue: 1. Remove old pavement (if available) Two. Clean, dry, unhaired skin 3. Preferred: lower belly, hip, buttocks 4. Pull off protective film, stick on plaster Five. 10 seconds tight 6. Adhesive site regularly change
Important notes:
- Don't stick to the chest!
- Not on irritated or injured skin
- When bathing/showing, the plaster can remain
- Not on the same place within 7 days
Contraindications
Do not apply at:
- Breast cancer
- estrogen-dependent tumors
- Unexplained vaginal bleeding
- Active thrombosis
- Heavy liver disease
Preview at:
- Thrombosis risk
- Migraine
- uterus myomas
- Endometriosis
- Diabetes, high blood pressure
Pregnant period: Contraindicated.
Possible Side Effects
Acid (1-10%):
- Skin reactions at the adhesive site
- Breast tensions
- Headaches
- Lubrication (in the beginning)
Occasionally:
- Mood changes
- nausea
- Blowing
- Weight gain
Selten:
- Thromboemboly (lower than oral HRT)
- bile stone diseases
** Skin reactions can be minimized by regularly changing the adhesive spot.
Interactions
Reactions:
- CYP3A4 inductors – possibly reduced effect
- Less interactions than oral HRT
** Transdermal application bypasses the first pass effect and therefore shows fewer interactions.
Frequently Asked Questions
Similar Medications
Is Estramon conti right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.