Why do I have to go to the bathroom more often?

Jardiance causes sugar to be excreted over urine. More water is also excreted, which leads to more frequent urination. This is a normal and desired effect. Ensure sufficient fluid supply.

What is a diabetic ketoacidosis?

A rare but serious complication where the body burns fat instead of sugar and forms ketone bodies. In SGLT2 inhibitors, it can also occur at normal blood sugar levels. In case of nausea, vomiting, abdominal pain or lack of breath to the doctor immediately.

Does Jardiance protect the heart?

Yeah. The EMPA REG-OUTCOME study showed that Empagliflozin significantly lowers the risk of cardiovascular death, heart attack and stroke in type 2 diabetes with heart disease. Jardiance is also approved for the treatment of heart failure.

Can I combine jardiance with metformin?

Yes, the combination is very common and sensible. Both drugs have different mechanisms and complement each other well. There is also a combination preparation (Synjardy®).

Jardiance

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What is Jardiance?

Jardiance contains the active ingredient Empagliflozin and belongs to the class of SGLT2 inhibitors (Gliflozine). It is used for the treatment of diabetes mellitus type 2 in adults.

Empagliflozin lowers blood sugar in a unique way: it causes excess sugar to be excreted over urine. This mechanism is independent of insulin, i.e. it also works in the case of declining insulin production.

Jardiance has shown a significant cardiovascular protection effect in the EMPA REG-OUTCOME study and is also approved for the treatment of heart failure. It is made by Boehringer Ingelheim.

Active Ingredients & Mechanism of Action

Active ingredient: Empagliflozin

Empagliflozin inhibits the sodium glucose cotransporter 2 (SGLT2) in the kidney:

Active mechanism:

SGLT2 is responsible for the resorption of about 90% of the filtered glucose in the kidney
By inhibiting this transporter, glucose is excreted with urine
Every day about 60-80 g of glucose are eliminated via urine

Additional effects:

Blood pressure reduction (by sodium and water loss)
Weight loss (by calorie loss via glucose in urine)
Cardiovascular protection
Nephroprotective effect

Insulin-independent: The mechanism of action is independent of insulin – the drug also works in advanced diabetes with reduced insulin production.

Who is it suitable for?

Jardiance is suitable for:

Adults with type 2 diabetes as a supplement to diet and exercise
As monotherapy (if metformin is not tolerated)
In combination with metformin, sulfonylureas or insulin
Diabetes patients with increased cardiovascular risk (especially benefits)
Patients with heart failure

Not suitable:

Diabetes type 1
Heavy kidney failure (eGFR < 20 ml/min for diabetes therapy)
Recurrent urinary path infections or genital fungal infections
Pregnancy and breastfeeding

Available Dosages

Available starches:

10 mg film tablets
25 mg film tablets

Recommended dosage:

Start dose: 10 mg once a day
If necessary and good compatibility: increase to 25 mg once a day

How to Take

Intake:

Once a day, preferably morning
Independent meals
Swallow tablet with water

Important notes:

Drinking sufficient liquid (dehydration risk)
Pay attention to signs of urinary infections or genital fungus
Regular kidney value controls
temporarily settle in case of illness, fever or dehydration (according to medical consultation)

Contraindications

**Jardiance must not be taken at:* *

Sensitivity to Empagliflozin
Diabetes type 1

Preview at:

Restricted kidney function (reduced effectiveness at low eGFR)
Sufficient to urinary tract infections
tilt to genital fungal infections
Older patients (>75 years – dehydration risk)
Simultaneous diuretics therapy
Increased risk of diabetic ketoacidosis

Pregnant period: Contraindicated. No use in pregnancy or breastfeeding.

Possible Side Effects

Acid (1-10%):

Genital fungal infections (veaginal fungus, balanitis)
urinary tract infections
Multiplying water (polyuria)
Hypoglycemia (in combination with insulin/sulfonylureas)

Occasionally:

Dehydration
dizziness, blood pressure drop
Itching
Blocking

Selten, but important:

Diabetic ketoacidosis (even with normal or only slightly elevated blood sugar levels – atypical!)
Fournier trenches (necrotizing perineum fasciitis – very rare)

** In case of symptoms such as nausea, vomiting, abdominal pain, unusual fatigue or lack of breath, immediately visit a doctor (Ketoazidose Concrete).

Interactions

Diuretics (dewatering agent): Enhanced dehydration and blood pressure reduction possible. Adjust dose if necessary.

Insulin and sulfonylureas: Hypoglycemia risk increases. Dose reduction may be necessary.

More information:

No clinically relevant interactions via CYP enzymes
Lithium mirrors can be influenced

Frequently Asked Questions

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Is Jardiance right for you?

A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.

Important Notice

This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.

Important Safety Information

This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.