What is prothyride?
Prothyride is a combination preparation of levothyroxin (T4) and liothyronin (T3) for the treatment of the thyroid subfunction. It contains the two thyroid hormones in a specific ratio and is used if a pure T4 therapy is not sufficient.
Like Novothyral, prothyride is aimed at patients who still feel symptoms of subfunction despite normal TSH values under L-thyroxin monotherapy. The ratio of T4 to T3 differs from Novothyral, which permits a more differentiated dosage.
The regulation is carried out individually by the treating endocrologist or internist.
Active Ingredients & Mechanism of Action
Active ingredient: Levothyroxin (T4) / Liothyronin (T3)
Prothyride supplies both thyroid hormones:
Levothyroxine (T4):
- Long effective prohormone
- Converts to T3 in tissue
- Provides basic supply with thyroid hormone
Liothyronine (T3):
- Biologically active form
- Faster action
- Shorter half-life (approx. 24 hours)
Rational combination: In some patients, the conversion of T4 to T3 in the tissue is restricted (e.g. by genetic variants of the deiodinase-2-enzyme). The direct T3-Gabe can in these cases improve the symptoms.
Who is it suitable for?
Prothyride can be suitable for:
- Patients with hypothyroidism and inadequate response to L-thyroxine
- For proven or suspected limited T4-T3 conversion
- In medical consideration as an alternative to Novothyral
Standard therapy remains L-thyroxin mono.
Not suitable for:
- coronary heart disease
- Heart rhythm disorders
- Osteoporosis (Preview)
- Older patients with cardiovascular risk factors
Available Dosages
Available strength:
- 100 mcg Levothyroxin + 10 mcg Liothyronin per tablet
Dosing:
- Individually according to laboratory findings (TSH, fT3, fT4)
- Mostly 1 tablet per day
- Close checks on therapy conversion
How to Take
Intake:
- Morning, sober, 30 minutes before breakfast
- With water (no coffee, no milk)
- Every day at the same time
Default:
- 2 h to calcium, iron, magnesium, antazida
- 4-5 h to cholestyramine
Controls:
- TSH, fT3 and fT4 regularly determine
- Especially at the beginning close-mesh (all 4-6 weeks)
Contraindications
**Prothyride must not be taken at:* *
- Untreated secondary bark insufficiency
- Acute heart attack, acute myocardialitis
- thyroid hyperfunction
Special caution (T3-share):
- coronary heart disease
- Heart rhythm disorders, atrial dimmers
- Older patients
- osteoporosis
pregnant: thyroid hormones are essential. If necessary, consider conversion to pure T4. Medical care required.
Possible Side Effects
For correct dosage: No side effects expected.
For overdose (particularly T3):
- cardiac arrhythmias
- Internal unrest, nervousness
- Sweating, thermal incompatibility
- trembling, sleep disorders
- diarrhea, weight loss
Long-term risks for overdose:
- osteoporosis
- Hopeful dimmers
Interactions
Like L-thyroxin:
- Calcium, Iron, Magnesium – Reduced absorption
- Cholestyramine – binds thyroid hormones
- estrogens – increased T4
- Anticoagulants – enhanced effect
Frequently Asked Questions
Similar Medications
Is prothyride right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor or pharmacist.
Important Safety Information
This service operates under German pharmaceutical law (HWG). For risks and side effects, read the package leaflet and consult your doctor or pharmacist. All medications are dispensed from a licensed pharmacy in Germany.